Written by Christina England, published in Health Impact News
Have you ever wondered why so many people, in particular those over the age of 65, react adversely to the flu vaccination? How many times have you heard that, after receiving the flu vaccine, a friend or loved one has developed flu-like symptoms?
At last, after many years of speculation, scientists in London believe they have the answer to our questions. A group of scientists led by Olga Sobolev from Kings College London believe that they have discovered why, after receiving flu vaccinations containing adjuvants, many healthy adults over the age 35 develop adverse reactions within hours of vaccination.
In a paper published by Nature Immunology titled Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events, they wrote:
Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions.
In simplified terms, this means that after completing complex immunological research, the team was able to determine why, after receiving the H1N1 flu vaccine containing an adjuvant, many of the recipients over the age of 35 developed flu-like adverse reactions within hours of vaccination.
Speaking from King’s College London, study co-author Adrian Hayday stated that:
The gene signature in the peripheral blood . . . is not a smoking gun at this point, but it’s a strong association and quite compelling.
The Scientist, one of the many leading medical journals reporting the news, stated that:
Previous studies have identified reasons why some people fail to respond to flu vaccines while others do, but few have analyzed the molecular correlates of adverse responses.
The researchers found no links between feeling sick after the vaccine and age, gender, or the quality of an individual’s immune response. However, they found that participants who reported severe adverse reactions had a transient increase in the expression of a small group of genes one day after they received the shot.
The Medical Xpress, another journal reporting on this paper wrote:
Scientists are eager to understand why some people experience such adverse reactions while others do not, because they believe it could lead to better vaccines, or perhaps even breakthroughs in understanding infections and the immune response.
You can read the rest of this article here.